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RecombiMAb anti-mouse CTLA-4 (CD152)（9D9-CP006單克隆抗體）介紹

更新時(shí)間：2024-09-13   點(diǎn)擊次數(shù)：201次

9D9-CP006單克隆抗體是原始9D9單克隆抗體的重組嵌合型抗體?？勺兘Y(jié)構(gòu)域序列與原始9D9克隆號(hào)相同，但是恒定區(qū)序列已經(jīng)從小鼠IgG2b變?yōu)樾∈驣gG1。9D9-CP006單克隆抗體能與小鼠CTLA-4(細(xì)胞毒性T淋巴細(xì)胞抗原-4)反應(yīng)，CTLA-4也稱為CD152。CTLA-4是一種33 kDa的細(xì)胞表面受體，由屬于免疫球蛋白超家族CD28家族的Ctla4基因編碼。CTLA-4在活化的T淋巴細(xì)胞和B淋巴細(xì)胞上表達(dá)。CTLA-4在結(jié)構(gòu)上類似于T細(xì)胞共刺激蛋白CD28，兩種分子都與B7家族成員B7-1 (CD80)和B7-2 (CD86)結(jié)合。在與配體結(jié)合時(shí)，CTLA-4負(fù)調(diào)節(jié)細(xì)胞介導(dǎo)的免疫反應(yīng)。CTLA-4在誘導(dǎo)和/或維持免疫耐受、胸腺細(xì)胞發(fā)育和保護(hù)性免疫調(diào)節(jié)中起作用。CTLA-4在免疫下調(diào)中的關(guān)鍵作用已經(jīng)在CTLA-4缺陷小鼠中得到證實(shí)，這些小鼠在3-5周齡時(shí)由于淋巴增生性疾病的發(fā)展而死亡。CTLA-4是目前腫瘤免疫檢查點(diǎn)治療的熱門(mén)靶點(diǎn)之一。

 

產(chǎn)品詳情：

產(chǎn)品名稱

RecombiMAb anti-mouse CTLA-4 (CD152)

產(chǎn)品貨號(hào)

CP006

產(chǎn)品規(guī)格

1mg

反應(yīng)種屬

Mouse

克隆號(hào)

9D9-CP006

同種型

Mouse IgG1(switched from mouse IgG2b)

免疫原

Not available or unknown

實(shí)驗(yàn)應(yīng)用

in vivo CTLA-4 neutralization*

Western blot*

*Reported for the original mouse IgG2b 9D9 antibody

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無(wú)菌處理

0.2 µm filtration

純化方式

Protein G

分子量

150 kDa

小鼠病原檢測(cè)

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C，不能冷凍保存。

推薦同型對(duì)照

InVivoPlus mouse IgG1 isotype control, unknown specificity（貨號(hào)BP0083）

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer（貨號(hào)IP0070）

 

該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：

應(yīng)用

文章

體內(nèi)CTLA-4中和

(in vivo CTLA-4 

neutralization)

1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally delivering 

combinations of immunomodulatory antibodies' Clin Cancer Res 21(5): 1127-1138.

2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates acquired 

resistance to agonistic anti-CD40 treatment' Cancer Immunol Res 3(3): 236-244.

3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory (OX40) 

and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of 

driving robust antitumor immunity' Cancer Immunol Res 2(2): 142-153.

4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived suppressor 

cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 124(6): 2626-2639.

5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in antibody-drug 

conjugates induce antitumor immunity by stimulation of dendritic cells' Cancer Immunol 

Res 2(8): 741-755.

6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute to the antitumor 

activities of immunoregulatory receptor-targeting antibodies' J Exp Med 210(9): 1685-1693.

 

 

 

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